此前曾有《生化危机4 重制版》已经全面投入制作，三上真司为本作提供了帮助的传闻。近日，外媒 VGC 称自己的消息来源从卡普空获悉，因制作意见存在分歧，《生化危机4 重制版》的开发工作已经重启，本作将在 2023 年推出。据传，《生化危机4 重制版》的开发工作由总部位于大阪的 M-Two 工作室负责。该工作室是白金工作室前负责人三并达也创立的新工作室，内部有许多从白金工作室和卡普空跳槽过来的开发者，该团队从 2018 年开始就一直为这个项目做准备。M-Two 工作室也负责了《生化危机3 重制版》的开发。但由于《生化危机3 重制版》表现不佳，多个消息来源表示在去年年底的一次关键项目审查之后，卡普空决定大幅降低 M-Two 工作室在《生化危机4 重制版》开发工作中的地位，并将本作的开发主导权转移给了曾开发《生化危机》
Before that, there was a rumor that "biochemical crisis quadruple plate making" had been fully put into production, and sanshangzhensi had provided help for this work. Recently, foreign media VGC said that its source learned from kapukong that due to differences in production opinions, the development of "biochemical crisis 4 remaking" has been restarted, and this work will be launched in 2023. It is said that m-two studio, which is headquartered in Osaka, is responsible for the development of "biochemical crisis 4 plate making". The studio is a new studio founded by sanbidaya, the former head of platinum studio. There are many developers who have transferred from platinum studio and kapukong. The team has been preparing for this project since 2018. M-two studio is also responsible for the development of "biochemical crisis 3 plate making". However, due to the poor performance of biochemical crisis 3 plate making, several sources said that after a key project review at the end of last year, kapukong decided to greatly reduce the position of m-two studio in the development of biochemical crisis 4 plate making, and transferred the development dominance of the work to the former developer of biochemical crisis
